Linda Cardellini
Lindsay Weir - 18 episoder

James Franco
Daniel Desario - 18 episoder

Samm Levine
Neal Schweiber - 18 episoder

Martin Starr
Bill Haverchuck - 18 episoder

Jason Segel
Nick Andopolis - 18 episoder

Seth Rogen
Ken Miller - 18 episoder

Busy Philipps
Kim Kelly - 18 episoder

Joe Flaherty
Harold Weir - 18 episoder

Becky Ann Baker
Jean Weir - 18 episoder

Steve Bannos
Frank Kowchevski - 12 episoder

Sarah Hagan
Millie Kentner - 11 episoder

Natasha Melnick
Cindy Sanders - 10 episoder

Stephen Lea Sheppard
Harris Trinsky - 10 episoder

Chauncey Leopardi
Alan White - 9 episoder

Dave Allen
Jeff Rosso - 9 episoder

Cynthia Windham
Audio Visual Teacher - 7 episoder

Trace Beaulieu
Hector Lacovara - 6 episoder

Thomas F. Wilson
Coach Ben Fredricks - 6 episoder

Riley Smith
Todd Schellinger - 5 episoder

JoAnna Garcia Swisher
Vicki Appleby - 5 episoder

Lizzy Caplan
Sara - 4 episoder

Sam McMurray
Dr. Vic Schweiber - 3 episoder

Matthew McKane
Mike Stevens - 3 episoder

Kayla Ewell
Maureen Sampson - 3 episoder

Ron Lester
Seidleman - 3 episoder

Jarrett Lennon
Colin - 3 episoder

Tom Virtue
Mr. Sampson - 2 episoder

Jessica Campbell
Amy Andrews - 2 episoder

Claudia Christian
Gloria Haverchuck - 2 episoder

Alan Simpson
Tom - 2 episoder

Ann Dowd
Cookie Kelly - 2 episoder

Ben Foster
Eli - 2 episoder

Samaire Armstrong
Laurie - 2 episoder

Amy Aquino
Mrs. Schweiber - 2 episoder

Stephanie Erb
Ms. Yeats - 2 episoder

Mark Allan Staubach
Mark - 2 episoder

Kevin Tighe
Mr. Andopolis - 2 episoder

Jerome Elston Scott
Disco Jermaine (uncredited) - 2 episoder

Jerry Messing
Gordon Crisp - 1 episoder

Kristy Wu
Mousy Girl - 1 episoder