Nathan Fillion
Mal Reynolds - 11 episoder

Gina Torres
Zoë Washburne - 11 episoder

Alan Tudyk
Hoban Washburne - 11 episoder

Morena Baccarin
Inara Serra - 11 episoder

Adam Baldwin
Jayne Cobb - 11 episoder

Jewel Staite
Kaylee Frye - 11 episoder

Sean Maher
Simon Tam - 11 episoder

Summer Glau
River Tam - 11 episoder

Ron Glass
Derrial Book - 11 episoder

Michael Fairman
Adelai Niska - 2 episoder

Jeff Ricketts
Blue Glove Man #1 - 1 episoder

Dennis Cockrum
Other Man - 1 episoder

Mark Sheppard
Badger - 2 episoder

Gregory Itzin
Magistrate Higgins - 1 episoder

Isabella Hofmann
Regan Tam - 1 episoder

Carlos Jacott
Lawrence Dobson - 1 episoder

Damion Poitier
Henchman - 1 episoder

Tom Towles
Lund - 1 episoder

Andrew Bryniarski
Crow - 1 episoder

Gregg Henry
Sheriff Bourne - 1 episoder

Doug Savant
Commander Harken - 1 episoder

Branden Morgan
Survivor - 1 episoder

Lancer Dean Shull
Radio Operator - 1 episoder

Benito Martinez
Boss - 1 episoder

Erik Passoja
Bree - 1 episoder

Bob Fimiani
Elder Gommen - 1 episoder

Daniel Bess
Mudder - 1 episoder

Kevin Gage
Stitch Hessian - 1 episoder

Zachary Kranzler
Fess Higgins - 1 episoder

Edward Atterton
Atherton Wing - 1 episoder

Larry Drake
Sir Warwick Harrow - 1 episoder

Carl Bresk
Wright - 1 episoder

Larry Pennell
Murphy - 1 episoder

William Converse-Roberts
Gabriel Tam - 1 episoder

John Thaddeus
Stark - 1 episoder

Gary Werntz
Patron - 1 episoder

Andy Rolfes
Marcus Grange / Older Grange - 1 episoder

Blake Robbins
Agent McGuinness - 1 episoder

Tom Virtue
Pompous Doctor - 1 episoder

Roma Chugani
Receiving Doctor - 1 episoder