Johnny Galecki
Leonard Hofstadter - 279 episoder

Jim Parsons
Sheldon Cooper - 279 episoder

Kaley Cuoco
Penny - 279 episoder

Simon Helberg
Howard Wolowitz - 279 episoder

Kunal Nayyar
Rajesh Koothrappali - 279 episoder

Melissa Rauch
Bernadette Rostenkowski - 221 episoder

Mayim Bialik
Amy Farrah Fowler - 217 episoder

Kevin Sussman
Stuart Bloom - 84 episoder

Carol Ann Susi
Debbie Wolowitz (voice) - 40 episoder

John Ross Bowie
Barry Kripke - 25 episoder

Laura Spencer
Emily Sweeney - 17 episoder

Wil Wheaton
Wil Wheaton - 17 episoder

Brian George
V.M. Koothrappali - 16 episoder

Christine Baranski
Beverly Hofstadter - 16 episoder

Brian Posehn
Bert Kibbler - 15 episoder

Laurie Metcalf
Mary Cooper - 14 episoder

Joshua Malina
President Siebert - 13 episoder

Aarti Mann
Priya Koothrappali - 12 episoder

Brian Thomas Smith
Zack Johnson - 11 episoder

Pamela Adlon
Halley Wolowitz (voice) - 10 episoder

Sara Gilbert
Leslie Winkle - 9 episoder

Rati Gupta
Anu - 9 episoder

Kate Micucci
Lucy - 8 episoder

Lauren Lapkus
Denise - 8 episoder

Stephen Hawking
Stephen Hawking - 7 episoder

Dean Norris
Richard Williams - 6 episoder

Casey Sander
Mike Rostenkowski - 6 episoder

Michael J. Massimino
Michael J. Massimino - 6 episoder

Regina King
Janine Davis - 6 episoder

Bob Newhart
Arthur Jeffries - 6 episoder

Alessandra Torresani
Claire - 5 episoder

Vernee Watson
Althea - 5 episoder

Mark Harelik
Eric Gablehauser - 5 episoder

Ed Lieberman
Announcer (voice) - 2 episoder

Keith Carradine
Wyatt Teller - 5 episoder

Pasha D. Lychnikoff
Dimitri - 5 episoder

Margo Harshman
Alex Jensen - 4 episoder

Robert Clotworthy
Announcer (voice) - 1 episoder

Brian Patrick Wade
Kurt - 3 episoder

LeVar Burton
LeVar Burton - 3 episoder