Clark Gregg
Phil Coulson - 123 episoder

Chloe Bennet
Daisy 'Skye' Johnson / Quake - 136 episoder

Elizabeth Henstridge
Jemma Simmons - 136 episoder

Ming-Na Wen
Melinda May - 136 episoder

Iain De Caestecker
Leo Fitz - 126 episoder

Henry Simmons
Alphonso 'Mack' Mackenzie - 114 episoder

Brett Dalton
Grant Ward - 46 episoder

Natalia Cordova-Buckley
Elena 'Yo-Yo' Rodriguez / Slingshot - 62 episoder

Jeff Ward
Deke Shaw - 45 episoder

Nick Blood
Lance Hunter - 45 episoder

Adrianne Palicki
Bobbi Morse - 44 episoder

Luke Mitchell
Lincoln Campbell - 27 episoder

John Hannah
Holden Radcliffe - 27 episoder

Maximilian Osinski
Davis - 27 episoder

Joel Stoffer
Enoch - 25 episoder

Adrian Pasdar
Glenn Talbot / Gravitron - 24 episoder

Gabriel Luna
Robbie Reyes / Ghost Rider - 22 episoder

B.J. Britt
Antoine Triplett - 21 episoder

Briana Venskus
Piper - 20 episoder

Mallory Jansen
Aida - 16 episoder

Ruth Negga
Raina - 16 episoder

Jason O'Mara
Jeffrey Mace / The Patriot - 14 episoder

Patrick Cavanaugh
Agent Burrows - 12 episoder

Kyle MacLachlan
The Doctor - 5 episoder

Dichen Lachman
Jiaying - 11 episoder

Mark Dacascos
Giyera - 11 episoder

Simon Kassianides
Sunil Bakshi - 10 episoder

Patton Oswalt
Billy Koenig / Sam Koenig - 3 episoder

Catherine Dent
General Hale - 10 episoder

J. August Richards
Mike Peterson / Deathlok - 10 episoder

Enver Gjokaj
Daniel Sousa - 10 episoder

Blair Underwood
Andrew Garner - 10 episoder

Powers Boothe
Gideon Malick - 10 episoder

Zach McGowan
Anton Ivanov - 9 episoder

Reed Diamond
Daniel Whitehall - 9 episoder

Jamie Harris
Gordon - 9 episoder

Coy Stewart
Flint - 9 episoder

Thomas E. Sullivan
Nathaniel Malick - 9 episoder

Brian Patrick Wade
Carl Creel - 9 episoder

Christine Adams
Agent Weaver - 8 episoder