Winona Ryder
Joyce Byers - 42 episoder

David Harbour
Jim Hopper - 42 episoder

Millie Bobby Brown
Eleven / Jane Hopper - 25 episoder

Finn Wolfhard
Mike Wheeler - 42 episoder

Gaten Matarazzo
Dustin Henderson - 42 episoder

Caleb McLaughlin
Lucas Sinclair - 42 episoder

Natalia Dyer
Nancy Wheeler - 42 episoder

Charlie Heaton
Jonathan Byers - 42 episoder

Joe Keery
Steve Harrington - 42 episoder

Noah Schnapp
Will Byers - 40 episoder

Cara Buono
Karen Wheeler - 38 episoder

Sadie Sink
Max Mayfield - 34 episoder

Priah Ferguson
Erica Sinclair - 29 episoder

Maya Hawke
Robin Buckley - 25 episoder

Brett Gelman
Murray - 25 episoder

Joe Chrest
Ted Wheeler - 23 episoder

Matthew Modine
Dr. Martin Brenner - 19 episoder

Paul Reiser
Dr. Sam Owens - 19 episoder

Dacre Montgomery
Billy Hargrove - 18 episoder

Jamie Campbell Bower
Vecna - 12 episoder

John Reynolds
Officer Callahan - 16 episoder

Rob Morgan
Officer Powell - 12 episoder

Randy Havens
Mr. Clarke - 15 episoder

Tinsley Price
Holly Wheeler - 15 episoder

Catherine Curtin
Claudia Henderson - 12 episoder

Sean Astin
Bob Newby - 10 episoder

Sherman Augustus
Lt. Col. Jack Sullivan - 11 episoder

Susan Shalhoub Larkin
Florence - 9 episoder

Clayton Royal Johnson
Andy - 10 episoder

Nell Fisher
Holly Wheeler - 8 episoder

Linda Hamilton
Dr. Kay - 8 episoder

Eduardo Franco
Argyle - 8 episoder

Linnea Berthelsen
Kali - 8 episoder

Mason Dye
Jason Carver - 8 episoder

Tom Wlaschiha
Dmitri Antonov - 8 episoder

Anniston Price
Holly Wheeler - 8 episoder

Aimee Mullins
Terry Ives - 7 episoder

Amybeth McNulty
Vickie - 8 episoder

Joseph Quinn
Eddie Munson - 8 episoder

Chester Rushing
Tommy H. - 7 episoder