Tom Payne
Malcolm Bright - 33 episoder

Michael Sheen
Dr. Martin Whitly - 33 episoder

Bellamy Young
Jessica Whitly - 33 episoder

Lou Diamond Phillips
Gil Arroyo - 33 episoder

Halston Sage
Ainsley Whitly - 33 episoder

Aurora Perrineau
Dani Powell - 33 episoder

Frank Harts
JT Tarmel - 33 episoder

Keiko Agena
Dr. Edrisa Tanaka - 33 episoder

Esau Pritchett
Mr. David - 21 episoder

Kasjan Wilson
Young Malcolm - 11 episoder

Molly Griggs
Eve Blanchard - 8 episoder

Catherine Zeta-Jones
Dr. Vivian Capshaw - 7 episoder

Anna Eilinsfeld
The Girl in the Box - 3 episoder

Christian Borle
Friar Pete - 6 episoder

Charlayne Woodard
Dr. Gabrielle Le Deux - 5 episoder

Armando Acevedo
Hector Cueto - 5 episoder

Raymond Lee
Jin - 3 episoder

Meagan Good
Colette Swanson - 3 episoder

Dermot Mulroney
Nicholas Endicott - 3 episoder

Michael Raymond-James
Paul Lazar / John Watkins / The Junkyard Killer - 3 episoder

April Hernandez Castillo
Marshal Emily Ruiz - 3 episoder

Matthew Maher
Tevin - 2 episoder

James Cusati-Moyer
Nico Stavros - 2 episoder

Meredith Garretson
Kimberly - 2 episoder

Marylouise Burke
Matilda Watkins - 2 episoder

Hettienne Park
Leslie - 2 episoder

Brian Stokes Mitchell
Everett Sterling - 2 episoder

Matthew Lawler
Eddie - 2 episoder

Richard H. Blake
Valet - 2 episoder

Matthew Montelongo
Officer O'Malley - 2 episoder

Michael Chernus
Jerry - 2 episoder

James Saito
Dr. Stanley Higa - 2 episoder

Alan Cumming
Simon Hoxley - 2 episoder

Sahr Ngaujah
Darryl - 2 episoder

Julianna Layne
Young Ainsley - 2 episoder

Peterson Townsend
Tech - 2 episoder

Michael Potts
Dr. Brandon Marsh - 2 episoder

Alan Gary
Burt - 2 episoder

Margaret Ivey
Didi Perrine - 2 episoder

Sakina Jaffrey
Dr. Elaine Brown - 1 episoder